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Synthetic antibacterial peptides are advanced weapons that scientists design and produce to confront current threats of harmful and mortal pathogens, which could affect humans in everyday life. Recently, many small amino acid sequences, greatly efficient in their antibacterial action, have been reported in the literature. To date, only a few synthetic peptides, acting at micromolar or even tenths of micromolar concentrations, are on the market as commercial products, mainly because of their high cost of production. In this context, materials science can provide fundamental help by engineering small synthetic peptides, powered by hybrid gold nanoparticles, which have been found to strongly enhance antimicrobial activity against bacterial infections. Submicromolar concentrations of the 1018K6 peptide, bioconjugated to hybrid polymer–gold nanoparticles, kill almost 100% of pathogen bacteria, such as Listeria and …
American Chemical Society
Publication date: 
23 Oct 2018

Gianna Palmieri, Rosarita Tatè, Marta Gogliettino, Marco Balestrieri, Ilaria Rea, Monica Terracciano, Yolande Therese Proroga, Federico Capuano, Aniello Anastasio, Luca De Stefano

Biblio References: 
Volume: 29 Issue: 11 Pages: 3877-3885
Bioconjugate chemistry